PeliCRM197® carrier protein made in Ligand’s Pelican Expression Technology® platform is the first and only commercially available CGMP CRM197 used in a marketed conjugate vaccine.

 A non-toxic mutant of diphtheria toxin, the PeliCRM197® carrier protein enhances the immunogenicity of antigens used in conjugate vaccines.


Assured supply of research & CGMP grade PeliCRM197®, from milligrams to kilograms, throughout development and commercialization.

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PeliCRM197® is supported by a Drug Master File (DMF) filed with the US FDA to simplify your regulatory submissions.  A comprehensive Regulatory Support Package is available for ex-US customers. 

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CRM197 produced in the Pelican Expression Technology® has an extensive safety record, with three approved and marketed products that are enabled by the technologyMultiple clinical studies are ongoing in infectious disease prevention and other areas, including Alzheimer’s.

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