PeliCRM197™ carrier protein made in Ligand’s Pelican Expression Technology™ platform is the first and only commercially available cGMP CRM197 used in a marketed conjugate vaccine.
A non-toxic mutant of diphtheria toxin, the PeliCRM197™ carrier protein functions as a conjugation substrate for polysaccharides and haptens to enhance the immunogenicity of antigens in conjugate vaccines. A 2018 publication comparing the quality attributes of the PeliCRM197™ carrier protein demonstrated it to be the highest purity CRM197 available (Hickey JM et al., Jour. Pharm. Sci., 2018 (1806-19)).